Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Lomitapide mesylate
Drug ID BADD_D01312
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status approved; investigational
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09638
MeSH ID C473731
PubChem ID 11274333
TTD Drug ID D0H8VY
NDC Product Code 76431-110; 76431-120; 11014-0361; 11014-0460; 11014-0360; 66039-923; 76431-130; 11014-0362; 11014-0461; 48957-0086; 76431-105; 11014-0359; 11014-0459; 70600-005
UNII X4S83CP54E
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C40H41F6N3O5S
CAS Registry Number 202914-84-9
SMILES CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6 =CC=CC=C64)C(=O)NCC(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Alanine aminotransferase13.03.04.002--Not Available
Alanine aminotransferase increased13.03.04.005--
Angina pectoris24.04.04.002; 02.02.02.002--
Aspartate aminotransferase13.03.04.008--Not Available
Back pain15.03.04.005--
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.003--Not Available
Constipation07.02.02.001--
Defaecation urgency07.02.04.001--Not Available
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dyspepsia07.01.02.001--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Headache17.14.01.001--
Hepatic steatosis09.01.07.003; 14.08.04.005--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Laryngeal pain22.12.03.010--
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Palpitations02.11.04.012--
Pyrexia08.05.02.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
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