| Pharmaceutical Information |
| Drug Name |
Lomitapide mesylate |
| Drug ID |
BADD_D01312 |
| Description |
Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). |
| Indications and Usage |
Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C). |
| Marketing Status |
approved; investigational |
| ATC Code |
C10AX12 |
| DrugBank ID |
DB08827
|
| KEGG ID |
D09638
|
| MeSH ID |
C473731
|
| PubChem ID |
11274333
|
| TTD Drug ID |
D0H8VY
|
| NDC Product Code |
76431-110; 76431-120; 11014-0361; 11014-0460; 11014-0360; 66039-923; 76431-130; 11014-0362; 11014-0461; 48957-0086; 76431-105; 11014-0359; 11014-0459; 70600-005 |
| UNII |
X4S83CP54E
|
| Synonyms |
BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733 |
|
| Chemical Information |
| Molecular Formula |
C40H41F6N3O5S |
| CAS Registry Number |
202914-84-9 |
| SMILES |
CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6
=CC=CC=C64)C(=O)NCC(F)(F)F |
| Chemical Structure |
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| ADRs Induced by Drug |
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