Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Loratadine
Drug ID BADD_D01317
Description Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
Indications and Usage Loratadine is a 2nd generation antihistamine and is used to manage symptoms of allergic rhinitis, wheal formation, urticaria, and other allergic dermatologic conditions.[A176435][A176438][L8486]
Marketing Status approved; investigational
ATC Code R06AX13
DrugBank ID DB00455
KEGG ID D00364
MeSH ID D017336
PubChem ID 3957
TTD Drug ID D06ABF
NDC Product Code 80070-110; 51927-4219; 59651-185; 63552-038; 65015-684; 11523-6655; 11523-7237; 11673-558; 21130-646; 36800-608; 36800-755; 37808-131; 41163-612; 41250-612; 41520-131; 43598-758; 49035-612; 49035-806; 51316-915; 53943-035; 55301-612; 56062-990; 57344-193; 58602-744; 58602-831; 59556-882; 59779-612; 0363-9937; 66715-6432; 67091-245; 67751-163; 68016-053; 68016-131; 68071-2801; 68071-2934; 68788-8349; 69230-328; 70000-0583; 70518-0135; 70518-1335; 70518-1399; 73581-203; 73581-230; 62331-018; 11523-7200; 11523-7202; 11822-0446; 11822-2022; 11822-8329; 41163-364; 46122-423; 49035-611; 50090-5506; 51316-503; 51660-106; 51660-526; 51672-2092; 55289-728; 55910-611; 55910-970; 56062-132; 57483-950; 59726-758; 60760-569; 62207-787; 0363-9994; 63941-131; 68016-167; 68071-2208; 68391-314; 68788-7291; 68998-414; 69452-211; 70518-2951; 70677-1053; 70985-017; 11014-0031; 62938-0005; 11523-0800; 11523-7157; 11673-115; 11673-612; 11822-0558; 11822-0919; 11822-3276; 21130-195; 21130-526; 21130-780; 21130-914; 21130-999; 0113-1019; 41250-629; 41250-890; 41520-716; 43598-756; 45802-650; 46122-539; 47682-203; 47682-403; 49035-953; 50090-4316; 50090-5067; 50090-5532; 50268-489; 51660-527; 51660-754; 54838-554; 55154-8082; 55681-303; 59726-915; 0363-2108; 0363-9150; 63941-193; 69168-414; 69230-317; 69230-322; 69842-085; 70000-0473; 55910-539; 55910-806; 59556-917; 62011-0248; 62011-0371; 0363-1612; 63548-0753; 0363-9603; 0363-9955; 63868-462; 0363-9995; 63868-669; 66715-6532; 67091-350; 68016-088; 68016-094; 68084-248; 69256-612; 0536-1367; 71335-0100; 0615-8217; 72983-500; 80070-120; 0904-6852; 59651-035; 11523-4328; 21130-301; 21130-452; 24385-543; 30142-017; 46122-550; 47682-913; 49348-818; 51672-2131; 51824-075; 53117-309; 55315-528; 58602-702; 58602-821; 58602-881; 61919-142; 63868-414; 63981-612; 67751-153; 68016-055; 68071-3412; 69842-686; 69842-894; 70000-0213; 82501-1580; 10888-8213; 61474-4268; 65015-803; 65691-0042; 66577-046; 11523-4329; 11523-4359; 11523-4364; 11673-986; 11673-996; 11822-0612; 0113-1191; 36800-853; 37205-378; 0113-9755; 41226-686; 41250-539; 43598-707; 51660-753; 55700-097; 57243-200; 60000-950; 63629-7772; 63868-151; 0378-8880; 67091-408; 68016-526; 68071-3414; 68210-4110; 69452-283; 69842-337; 69842-895; 70000-0125; 71335-1461; 72036-193; 72288-446; 72288-451; 72888-029; 10888-8212; 66577-012; 68554-0003; 11523-0007; 11523-4330; 11523-7333; 11822-9999; 16714-898; 30142-446; 0113-7671; 49035-061; 50090-1454; 51316-502; 51660-112; 51672-2085; 55154-4375; 56062-526; 57483-955; 58602-818; 58602-830; 58602-847; 59556-301; 62011-0348; 0363-0771; 0363-0858; 63187-100; 64024-023; 66715-9732; 68196-301; 68391-301; 68788-7653; 69842-242; 69842-540; 69842-953; 70264-030; 71309-007; 72983-501; 80159-103; 81522-612; 38779-2857; 51552-1210; 62993-0803; 63827-0001; 65015-802; 11523-1527; 11523-4331; 11523-7160; 11822-0620; 25000-021; 30142-723; 30142-984; 33992-0612; 0113-7612; 37808-506; 41520-612; 47682-912; 49738-686; 50090-6164; 50594-010; 52904-630; 54838-558; 55319-099; 55910-594; 59779-528; 0363-0752; 0363-0754; 63868-577; 68071-2971; 68998-309; 69168-309; 69848-019; 70000-0252; 70010-162; 70677-0029; 70677-0145; 71335-1651; 49452-4135; 11673-111; 11822-2131; 11822-7240; 16571-822; 30142-612; 0113-1719; 41250-716; 49035-538; 50090-0836; 53943-116; 53943-975; 56062-900; 62011-0305; 0363-0699; 0363-1686; 0363-2131; 0363-4020
UNII 7AJO3BO7QN
Synonyms Loratadine | 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester | Claritin | Sch-29851 | Sch 29851 | Sch29851 | Alavert | Clarium
Chemical Information
Molecular Formula C22H23ClN2O2
CAS Registry Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rhabdomyolysis15.05.05.0020.000032%
Rheumatoid arthritis15.01.03.001; 10.04.06.0010.000032%Not Available
Rhinorrhoea22.12.03.0210.000180%
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.0010.000264%
Shock24.06.02.002--Not Available
Sinus headache22.12.03.022; 17.14.01.0020.000032%
Skin disorder23.03.03.007--Not Available
Sleep disorder19.02.04.0010.000103%Not Available
Sneezing22.12.03.0240.000377%
Somnolence19.02.05.003; 17.02.04.0060.000850%
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.000103%Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.01.0450.000032%
Suicide attempt19.12.01.0040.000080%
Swelling08.01.03.0150.000164%Not Available
Swelling face23.04.01.018; 08.01.03.100; 10.01.05.0180.000177%Not Available
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.000135%Not Available
Syncope17.02.04.008; 02.11.04.015; 24.06.02.0120.000161%
Tachycardia02.03.02.0070.000222%Not Available
Tension19.06.02.0050.000071%Not Available
Therapeutic response decreased08.06.01.016--Not Available
Therapeutic response unexpected08.06.01.0010.000399%Not Available
Thirst14.03.02.007; 08.01.09.0210.000032%Not Available
Throat irritation22.12.03.029; 07.05.05.0370.000274%Not Available
Throat tightness22.12.03.031; 19.01.02.0050.000064%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.000126%
Tremor17.01.06.002--
Tunnel vision17.17.01.013; 06.02.07.0050.000080%Not Available
Urinary retention20.02.02.0110.000064%
Urticaria10.01.06.001; 23.04.02.0010.000444%
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