Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Loratadine
Drug ID BADD_D01317
Description Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
Indications and Usage Loratadine is a 2nd generation antihistamine and is used to manage symptoms of allergic rhinitis, wheal formation, urticaria, and other allergic dermatologic conditions.[A176435][A176438][L8486]
Marketing Status approved; investigational
ATC Code R06AX13
DrugBank ID DB00455
KEGG ID D00364
MeSH ID D017336
PubChem ID 3957
TTD Drug ID D06ABF
NDC Product Code 80070-110; 51927-4219; 59651-185; 63552-038; 65015-684; 11523-6655; 11523-7237; 11673-558; 21130-646; 36800-608; 36800-755; 37808-131; 41163-612; 41250-612; 41520-131; 43598-758; 49035-612; 49035-806; 51316-915; 53943-035; 55301-612; 56062-990; 57344-193; 58602-744; 58602-831; 59556-882; 59779-612; 0363-9937; 66715-6432; 67091-245; 67751-163; 68016-053; 68016-131; 68071-2801; 68071-2934; 68788-8349; 69230-328; 70000-0583; 70518-0135; 70518-1335; 70518-1399; 73581-203; 73581-230; 62331-018; 11523-7200; 11523-7202; 11822-0446; 11822-2022; 11822-8329; 41163-364; 46122-423; 49035-611; 50090-5506; 51316-503; 51660-106; 51660-526; 51672-2092; 55289-728; 55910-611; 55910-970; 56062-132; 57483-950; 59726-758; 60760-569; 62207-787; 0363-9994; 63941-131; 68016-167; 68071-2208; 68391-314; 68788-7291; 68998-414; 69452-211; 70518-2951; 70677-1053; 70985-017; 11014-0031; 62938-0005; 11523-0800; 11523-7157; 11673-115; 11673-612; 11822-0558; 11822-0919; 11822-3276; 21130-195; 21130-526; 21130-780; 21130-914; 21130-999; 0113-1019; 41250-629; 41250-890; 41520-716; 43598-756; 45802-650; 46122-539; 47682-203; 47682-403; 49035-953; 50090-4316; 50090-5067; 50090-5532; 50268-489; 51660-527; 51660-754; 54838-554; 55154-8082; 55681-303; 59726-915; 0363-2108; 0363-9150; 63941-193; 69168-414; 69230-317; 69230-322; 69842-085; 70000-0473; 55910-539; 55910-806; 59556-917; 62011-0248; 62011-0371; 0363-1612; 63548-0753; 0363-9603; 0363-9955; 63868-462; 0363-9995; 63868-669; 66715-6532; 67091-350; 68016-088; 68016-094; 68084-248; 69256-612; 0536-1367; 71335-0100; 0615-8217; 72983-500; 80070-120; 0904-6852; 59651-035; 11523-4328; 21130-301; 21130-452; 24385-543; 30142-017; 46122-550; 47682-913; 49348-818; 51672-2131; 51824-075; 53117-309; 55315-528; 58602-702; 58602-821; 58602-881; 61919-142; 63868-414; 63981-612; 67751-153; 68016-055; 68071-3412; 69842-686; 69842-894; 70000-0213; 82501-1580; 10888-8213; 61474-4268; 65015-803; 65691-0042; 66577-046; 11523-4329; 11523-4359; 11523-4364; 11673-986; 11673-996; 11822-0612; 0113-1191; 36800-853; 37205-378; 0113-9755; 41226-686; 41250-539; 43598-707; 51660-753; 55700-097; 57243-200; 60000-950; 63629-7772; 63868-151; 0378-8880; 67091-408; 68016-526; 68071-3414; 68210-4110; 69452-283; 69842-337; 69842-895; 70000-0125; 71335-1461; 72036-193; 72288-446; 72288-451; 72888-029; 10888-8212; 66577-012; 68554-0003; 11523-0007; 11523-4330; 11523-7333; 11822-9999; 16714-898; 30142-446; 0113-7671; 49035-061; 50090-1454; 51316-502; 51660-112; 51672-2085; 55154-4375; 56062-526; 57483-955; 58602-818; 58602-830; 58602-847; 59556-301; 62011-0348; 0363-0771; 0363-0858; 63187-100; 64024-023; 66715-9732; 68196-301; 68391-301; 68788-7653; 69842-242; 69842-540; 69842-953; 70264-030; 71309-007; 72983-501; 80159-103; 81522-612; 38779-2857; 51552-1210; 62993-0803; 63827-0001; 65015-802; 11523-1527; 11523-4331; 11523-7160; 11822-0620; 25000-021; 30142-723; 30142-984; 33992-0612; 0113-7612; 37808-506; 41520-612; 47682-912; 49738-686; 50090-6164; 50594-010; 52904-630; 54838-558; 55319-099; 55910-594; 59779-528; 0363-0752; 0363-0754; 63868-577; 68071-2971; 68998-309; 69168-309; 69848-019; 70000-0252; 70010-162; 70677-0029; 70677-0145; 71335-1651; 49452-4135; 11673-111; 11822-2131; 11822-7240; 16571-822; 30142-612; 0113-1719; 41250-716; 49035-538; 50090-0836; 53943-116; 53943-975; 56062-900; 62011-0305; 0363-0699; 0363-1686; 0363-2131; 0363-4020
UNII 7AJO3BO7QN
Synonyms Loratadine | 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester | Claritin | Sch-29851 | Sch 29851 | Sch29851 | Alavert | Clarium
Chemical Information
Molecular Formula C22H23ClN2O2
CAS Registry Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000087%
Abdominal pain07.01.05.0020.000386%
Abdominal pain lower07.01.05.0100.000071%Not Available
Abdominal pain upper07.01.05.0030.000097%
Abortion spontaneous18.01.04.0010.000064%Not Available
Aggression19.05.01.0010.000080%Not Available
Agitation19.06.02.001; 17.02.05.0120.000080%
Alopecia23.02.02.0010.000161%
Altered state of consciousness19.07.01.003; 17.02.04.0010.000048%Not Available
Amnesia19.20.01.001; 17.03.02.0010.000080%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000071%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.000064%Not Available
Anhedonia19.15.02.0070.000032%Not Available
Anxiety19.06.02.0020.000232%
Application site erythema23.03.06.005; 12.07.01.001; 08.02.01.0010.000032%Not Available
Arrhythmia02.03.02.0010.000145%Not Available
Arthralgia15.01.02.0010.000261%
Asthenia08.01.01.0010.000286%Not Available
Asthma10.01.03.010; 22.03.01.0020.000048%Not Available
Atrial fibrillation02.03.03.0020.000087%
Back pain15.03.04.0050.000167%
Blister23.03.01.001; 12.01.06.002--Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000071%Not Available
Calculus urinary20.04.03.0020.000064%Not Available
Cardiovascular disorder24.03.02.009; 02.11.01.010--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000032%Not Available
Cerebral venous thrombosis24.01.04.005; 17.08.03.0020.000032%Not Available
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