Pharmaceutical Information |
Drug Name |
Macitentan |
Drug ID |
BADD_D01336 |
Description |
Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. |
Indications and Usage |
Macitentan is indicated for the treatment of WHO group 1 pulmonary arterial hypertension (PAH) both alone and in combination with tadalafil.[L39105, L39105] |
Marketing Status |
approved |
ATC Code |
C02KX04 |
DrugBank ID |
DB08932
|
KEGG ID |
D10135
|
MeSH ID |
C533860
|
PubChem ID |
16004692
|
TTD Drug ID |
D0S7JH
|
NDC Product Code |
65015-872; 11722-058; 66215-501; 68225-070; 69037-0030; 76397-014; 59651-122; 82245-0117; 69766-006 |
UNII |
Z9K9Y9WMVL
|
Synonyms |
macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit |
|
Chemical Information |
Molecular Formula |
C19H20Br2N6O4S |
CAS Registry Number |
441798-33-0 |
SMILES |
CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br |
Chemical Structure |
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ADRs Induced by Drug |
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