Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Magnesium sulfate
Drug ID BADD_D01343
Description A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Indications and Usage Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
Marketing Status approved; investigational; vet_approved
ATC Code A06AD04; A12CC02; B05XA05; D11AX05; V04CC02
DrugBank ID DB00653
KEGG ID D01108
MeSH ID D008278
PubChem ID 24083
TTD Drug ID D02LDN
NDC Product Code 41250-602; 41250-929; 44567-424; 52862-203; 55319-395; 58037-008; 67091-352; 0409-1754; 69256-395; 71569-602; 72288-602; 21130-970; 30400-210; 63941-602; 0404-9904; 68998-395; 69842-602; 36800-602; 41190-602; 50594-602; 51662-1373; 52584-064; 52584-642; 0363-0395; 63940-602; 68016-732; 55315-395; 62011-0362; 76162-029; 67706-0006; 44567-420; 52862-202; 55910-648; 0404-9902; 0409-2168; 0869-0602; 49452-4302; 44567-421; 44567-422; 56062-952; 63940-080; 21130-602; 37012-602; 41163-602; 42681-6412; 55319-572; 63868-602; 68196-395; 70000-0614; 11673-200; 11673-602; 42681-6413; 55312-029; 72476-602; 55570-310; 20276-330; 30142-602; 36800-395; 44567-423; 50438-001; 51662-1352; 51662-1390; 55316-602; 55910-038; 0363-0942; 49035-602; 51662-1372; 51662-1451; 56062-602; 0395-0807; 70000-0021; 44567-410; 51316-395; 53943-602; 55301-602
UNII ML30MJ2U7I
Synonyms Magnesium Sulfate | Sulfate, Magnesium | Magnesium Sulfate, Heptahydrate | Heptahydrate Magnesium Sulfate
Chemical Information
Molecular Formula MgSO4
CAS Registry Number 7487-88-9
SMILES [O-]S(=O)(=O)[O-].[Mg+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure decreased13.14.03.002--Not Available
Constipation07.02.02.001--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypocalcaemia14.04.01.004--
Hypothermia12.05.03.001; 08.05.01.003--
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Stupor17.02.04.007; 19.02.05.004--Not Available
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