Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mecamylamine
Drug ID BADD_D01356
Description A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Indications and Usage For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Marketing Status approved; investigational
ATC Code C02BB01
DrugBank ID DB00657
KEGG ID Not Available
MeSH ID D008464
PubChem ID 4032
TTD Drug ID D0V8HA
NDC Product Code Not Available
UNII 6EE945D3OK
Synonyms Mecamylamine
Chemical Information
Molecular Formula C11H21N
CAS Registry Number 60-40-2
SMILES CC1(C2CCC(C2)C1(C)NC)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Chorea17.01.01.001--Not Available
Constipation07.02.02.001--
Dizziness17.02.05.003; 02.11.04.006; 24.06.02.007--
Dizziness postural02.11.04.008; 24.06.02.008; 17.02.05.004--Not Available
Fatigue08.01.01.002--
Fibrosis08.03.01.001--Not Available
Glossitis07.14.01.001--Not Available
Ileus07.13.01.001--
Libido decreased21.03.02.005; 19.08.03.001--
Loss of consciousness17.02.04.004--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Syncope17.02.04.008; 02.11.04.015; 24.06.02.012--
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Disturbance in sexual arousal19.08.04.003--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
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ADReCS-Target
Drug Name ADR Term Target
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