| Pharmaceutical Information |
| Drug Name |
Mephenytoin |
| Drug ID |
BADD_D01386 |
| Description |
Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and Cytochrome P450 2D6 are known to metabolize mephenytoin. Mephenytoin is a hydantoin-derivative anticonvulsant used to control various partial seizures. Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias compared to other anticonvulsants. |
| Indications and Usage |
For the treatment of refractory partial epilepsy. |
| Marketing Status |
approved; investigational; withdrawn |
| ATC Code |
N03AB04 |
| DrugBank ID |
DB00532
|
| KEGG ID |
D00375
|
| MeSH ID |
D008617
|
| PubChem ID |
4060
|
| TTD Drug ID |
D07RGW
|
| NDC Product Code |
Not Available |
| UNII |
R420KW629U
|
| Synonyms |
Mephenytoin | 5-Ethyl-3-Methyl-5-Phenylhydantoin | 5 Ethyl 3 Methyl 5 Phenylhydantoin | Mefenetoin | Methoin | Methyl Phenetoin | Phenetoin, Methyl | Phenantoin | Mesantoin |
|
| Chemical Information |
| Molecular Formula |
C12H14N2O2 |
| CAS Registry Number |
50-12-4 |
| SMILES |
CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2 |
| Chemical Structure |
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| ADRs Induced by Drug |
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