Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mercaptopurine
Drug ID BADD_D01392
Description An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Indications and Usage For remission induction and maintenance therapy of acute lymphatic leukemia.
Marketing Status approved
ATC Code L01BB02
DrugBank ID DB01033
KEGG ID D00161; D04931
MeSH ID D015122
PubChem ID 667490
TTD Drug ID D09UZO
NDC Product Code 62991-2899; 69076-913; 15308-0712; 12780-0299; 0054-4581; 0378-3547
UNII E7WED276I5
Synonyms Mercaptopurine | 6H-Purine-6-thione, 1,7-dihydro- | 6-Mercaptopurine Monohydrate | 6 Mercaptopurine Monohydrate | 6-Thiopurine | 6 Thiopurine | 1,7-Dihydro-6H-purine-6-thione | 6-Mercaptopurine | 6 Mercaptopurine | 6-Thiohypoxanthine | 6 Thiohypoxanthine | Purinethol | Puri-Nethol | Mercaptopurina Wellcome | Leupurin | BW 57-323H | BW 57 323H | BW 57323H | Purimethol | Mecaptopurine Anhydrous
Chemical Information
Molecular Formula C5H4N4S
CAS Registry Number 50-44-2
SMILES C1=NC2=C(N1)C(=S)N=CN2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast pain21.05.05.003--
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Chills08.01.09.001; 15.05.03.0160.003331%
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.0010.003851%Not Available
Coagulopathy01.01.02.0010.003123%Not Available
Colitis07.08.01.0010.001561%
Colitis ulcerative10.02.01.004; 07.08.01.0050.003123%Not Available
Colon cancer16.13.01.001; 07.21.01.001--Not Available
Condition aggravated08.01.03.004--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.011658%Not Available
Crying08.01.03.005; 19.04.02.002; 17.02.05.013; 12.02.11.001--Not Available
Cyst16.02.02.002; 08.03.05.001--Not Available
Defaecation urgency07.02.04.001--Not Available
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.0010.001561%Not Available
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.002082%Not Available
Diffuse large B-cell lymphoma16.28.02.001; 01.15.02.0010.007807%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Drug ineffective08.06.01.006--Not Available
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia22.12.03.006; 19.19.03.002; 17.02.08.004--
Ear pain04.03.01.003--
Encephalopathy17.13.02.0010.001041%
Enteritis07.08.03.0020.001561%
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ADReCS-Target
Drug Name ADR Term Target
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