Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mercaptopurine
Drug ID BADD_D01392
Description An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Indications and Usage For remission induction and maintenance therapy of acute lymphatic leukemia.
Marketing Status approved
ATC Code L01BB02
DrugBank ID DB01033
KEGG ID D00161; D04931
MeSH ID D015122
PubChem ID 667490
TTD Drug ID D09UZO
NDC Product Code 62991-2899; 69076-913; 15308-0712; 12780-0299; 0054-4581; 0378-3547
UNII E7WED276I5
Synonyms Mercaptopurine | 6H-Purine-6-thione, 1,7-dihydro- | 6-Mercaptopurine Monohydrate | 6 Mercaptopurine Monohydrate | 6-Thiopurine | 6 Thiopurine | 1,7-Dihydro-6H-purine-6-thione | 6-Mercaptopurine | 6 Mercaptopurine | 6-Thiohypoxanthine | 6 Thiohypoxanthine | Purinethol | Puri-Nethol | Mercaptopurina Wellcome | Leupurin | BW 57-323H | BW 57 323H | BW 57323H | Purimethol | Mecaptopurine Anhydrous
Chemical Information
Molecular Formula C5H4N4S
CAS Registry Number 50-44-2
SMILES C1=NC2=C(N1)C(=S)N=CN2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema23.03.06.0010.002082%Not Available
Eye disorder06.08.03.001--Not Available
Faeces discoloured07.01.03.002--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.003123%
Feeling hot08.01.09.009--Not Available
Fistula15.03.02.0010.001041%Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.007--
Flatulence07.01.04.002--
Frequent bowel movements07.02.04.002--Not Available
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.0010.004684%Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematochezia24.07.02.012; 07.12.02.0030.001561%Not Available
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.004--Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.002082%Not Available
Hepatic fibrosis24.08.06.002; 09.01.04.0020.002290%Not Available
Hepatic necrosis09.01.07.0020.001041%
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.0080.001561%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.012699%Not Available
Hernia08.01.04.001--Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.001041%Not Available
Hyperhidrosis08.01.03.028; 23.02.03.0040.001561%
Hypersensitivity10.01.03.003--
Hypersplenism01.09.02.0020.001041%Not Available
Hyperuricaemia14.09.01.003--
Hypoaesthesia23.03.03.081; 17.02.06.0230.006141%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene