Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mercaptopurine
Drug ID BADD_D01392
Description An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Indications and Usage For remission induction and maintenance therapy of acute lymphatic leukemia.
Marketing Status approved
ATC Code L01BB02
DrugBank ID DB01033
KEGG ID D00161; D04931
MeSH ID D015122
PubChem ID 667490
TTD Drug ID D09UZO
NDC Product Code 62991-2899; 69076-913; 15308-0712; 12780-0299; 0054-4581; 0378-3547
UNII E7WED276I5
Synonyms Mercaptopurine | 6H-Purine-6-thione, 1,7-dihydro- | 6-Mercaptopurine Monohydrate | 6 Mercaptopurine Monohydrate | 6-Thiopurine | 6 Thiopurine | 1,7-Dihydro-6H-purine-6-thione | 6-Mercaptopurine | 6 Mercaptopurine | 6-Thiohypoxanthine | 6 Thiohypoxanthine | Purinethol | Puri-Nethol | Mercaptopurina Wellcome | Leupurin | BW 57-323H | BW 57 323H | BW 57323H | Purimethol | Mecaptopurine Anhydrous
Chemical Information
Molecular Formula C5H4N4S
CAS Registry Number 50-44-2
SMILES C1=NC2=C(N1)C(=S)N=CN2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.014781%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abortion18.01.01.001--Not Available
Abortion spontaneous18.01.04.0010.001041%Not Available
Acne23.02.01.001--Not Available
Acute lymphocytic leukaemia16.01.01.001; 01.10.01.0010.001041%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.002082%Not Available
Alopecia23.02.02.0010.011554%
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.011450%
Anal fissure07.03.01.002--
Anal fistula07.11.05.0020.001041%
Angina pectoris24.04.04.002; 02.02.02.002--
Angiocentric lymphoma16.17.04.002; 01.11.04.0020.002082%Not Available
Anorectal disorder07.03.01.001--Not Available
Aphthous ulcer07.05.06.002--Not Available
Arthralgia15.01.02.0010.003851%
Arthritis15.01.01.001--
Ascites02.05.04.002; 09.01.05.003; 07.07.01.0010.001041%
Azoospermia21.03.03.001--
B-cell lymphoma16.28.01.001; 01.15.01.0010.002602%Not Available
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Blood bilirubin increased13.03.04.018--
Blood pressure fluctuation24.06.01.002--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
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ADReCS-Target
Drug Name ADR Term Target
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