| Pharmaceutical Information |
| Drug Name |
Methacholine chloride |
| Drug ID |
BADD_D01404 |
| Description |
Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in which the smooth muscle in the airways (ASM) excessively contracts in response to stimuli, reducing pulmonary function and causing symptoms such as difficulty breathing.[A229598, A229603] Although the underlying pathology of AHR is complex, ASM contraction can be stimulated by cholinergic agonists that activate M3 muscarinic receptors that stimulate ASM contraction.[A229603, A229618, A229643] Methacholine is a non-specific cholinergic agonist (parasympathomimetic) that acts through muscarinic receptors in the lungs to induce bronchoconstriction.[L31763] In patients with AHR, a lower dose of methacholine is required to induce bronchoconstriction, which forms the basis for the methacholine challenge test to diagnose AHR.[A229648, L31763]
Methacholine was granted FDA approval on October 31, 1986, and is marketed under the trademark PROVOCHOLINE® by Methapharm Inc.[L31763] |
| Indications and Usage |
Methacholine is indicated in adult and pediatric patients aged five years and older without clinically apparent asthma for the diagnosis of bronchial airway hyperactivity via the methacholine challenge test.[L31763] |
| Marketing Status |
approved; investigational |
| ATC Code |
V04CX03 |
| DrugBank ID |
DB06709
|
| KEGG ID |
D04970
|
| MeSH ID |
D016210
|
| PubChem ID |
6114
|
| TTD Drug ID |
D04MWJ
|
| NDC Product Code |
64281-100; 54236-010 |
| UNII |
0W5ETF9M2K
|
| Synonyms |
Methacholine Chloride | Chloride, Methacholine | Acetyl-beta-methacholine Chloride | Acetyl beta methacholine Chloride | Mecholine | 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride | Acetyl-2-methylcholine Chloride | Acetyl 2 methylcholine Chloride | Mecholyl | Provocholine | Provokit | Acetyl-beta-methylcholine | Acetyl beta methylcholine | Methacholine |
|
| Chemical Information |
| Molecular Formula |
C8H18ClNO2 |
| CAS Registry Number |
62-51-1 |
| SMILES |
CC(C[N+](C)(C)C)OC(=O)C.[Cl-] |
| Chemical Structure |
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| ADRs Induced by Drug |
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