| Drug Name |
Midazolam |
| Drug ID |
BADD_D01459 |
| Description |
Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties.[A173842] It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.[A173842] Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.[F2977]
This drug was initially approved by the US FDA in 1985, and has been approved for various indications since.[FDA label] In late 2018, the intramuscular preparation was approved by the FDA for the treatment of status epilepticus in adults.[FDA label] In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive intermittent, stereotypic seizure episodes in patients 12 years of age and older. Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.[L5074] |
| Indications and Usage |
**Intravenous**
Indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, or amnesia.[F2434]
**Intramuscular**
Indicated for the treatment of status epilepticus in adults.[FDA label]
**Nasal**
Indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 12 years of age and older.[L6559] |
| Marketing Status |
approved; illicit |
| ATC Code |
N05CD08 |
| DrugBank ID |
DB00683
|
| KEGG ID |
D00550
|
| MeSH ID |
D008874
|
| PubChem ID |
4192
|
| TTD Drug ID |
D0U6LM
|
| NDC Product Code |
0641-6056; 0641-6061; 0641-6063; 0404-9912; 0404-9913; 0404-9915; 72611-741; 0641-6060; 82393-117; 72572-430; 0641-6209; 0641-6210; 17511-115; 51927-0001; 72611-749; 0641-6057; 0641-6190; 50474-500; 51552-1023; 72572-432; 0641-6211; 48087-0098; 52584-059; 12828-0069; 49452-4721; 67763-100; 0641-6059; 63275-9925; 79037-001 |
| UNII |
R60L0SM5BC
|
| Synonyms |
Midazolam | Midazolam Maleate | Maleate, Midazolam | Dormicum | Versed | Midazolam Hydrochloride | Hydrochloride, Midazolam | Ro 21-3981 | Ro 21 3981 | Ro 213981 |
