Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Midodrine
Drug ID BADD_D01461
Description An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Indications and Usage For the treatment of symptomatic orthostatic hypotension (OH).
Marketing Status approved
ATC Code C01CA17
DrugBank ID DB00211
KEGG ID D08220
MeSH ID D008879
PubChem ID 4195
TTD Drug ID D02XJY
NDC Product Code Not Available
UNII 6YE7PBM15H
Synonyms Midodrine | Midodrin | Midodrine Hydrochloride | Midodrine Monohydrochloride | Monohydrochloride, Midodrine | ProAmatine | Amatine | ST-1085 | ST 1085 | ST1085 | Gutron | Midon
Chemical Information
Molecular Formula C12H18N2O4
CAS Registry Number 42794-76-3
SMILES COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperaesthesia23.03.03.080; 17.02.06.004--Not Available
Hypersensitivity10.01.03.0030.002528%
Hypertension24.08.02.0010.000972%
Hypotension24.06.03.0020.001296%
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Micturition urgency20.02.02.006--
Muscle spasms15.05.03.004--
Nausea07.01.07.0010.003046%
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Pain08.01.08.004--
Paraesthesia23.03.03.094; 17.02.06.005--
Piloerection23.02.06.005--Not Available
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Retinal vein occlusion24.01.07.006; 06.10.01.010--Not Available
Seizure17.12.03.0010.000972%
Skin disorder23.03.03.007--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stomatitis07.05.06.005--
Suicide attempt19.12.01.0040.000972%
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.000648%
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.011--
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