Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Mitoxantrone hydrochloride
Drug ID BADD_D01481
Description An anthracenedione-derived antineoplastic agent.
Indications and Usage For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Marketing Status approved; investigational
ATC Code L01DB07
DrugBank ID DB01204
KEGG ID D02166
MeSH ID D008942
PubChem ID 51082
TTD Drug ID D0R3JB
NDC Product Code 58598-0005; 63323-132
UNII U6USW86RD0
Synonyms Mitoxantrone | Mitozantrone | DHAQ | NSC-279836 | NSC 279836 | NSC279836 | NSC-287836 | NSC 287836 | NSC287836 | NSC-299195 | NSC 299195 | NSC299195 | NSC-301739 | NSC 301739 | NSC301739 | NSC-301739D | NSC 301739D | NSC301739D | Mitroxone | Pralifan | CL-232325 | CL 232325 | CL232325 | Mitoxantrone Acetate | Acetate, Mitoxantrone | Mitoxantrone Hydrochloride | Hydrochloride, Mitoxantrone | Novantrone | Ralenova | Novantron | Onkotrone
Chemical Information
Molecular Formula C22H30Cl2N4O6
CAS Registry Number 70476-82-3
SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Ecchymosis01.01.03.001; 24.07.06.002; 23.06.01.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Endocrine disorder05.09.01.001--Not Available
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.002--
Febrile neutropenia01.02.03.002; 08.05.02.004--
Foot and mouth disease23.11.05.002; 11.05.04.020; 07.05.07.010--Not Available
Fungal infection11.03.05.001--Not Available
Gamma-glutamyltransferase increased13.03.04.024--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Granulocytes abnormal13.01.06.034--Not Available
Granulocytopenia01.02.03.003--Not Available
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.003--Not Available
Headache17.14.01.001--
Hepatomegaly09.01.05.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypertension24.08.02.001--
Hypocalcaemia14.04.01.004--
Hypokalaemia14.05.03.002--
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Infertility21.03.02.001--Not Available
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