Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Mitoxantrone hydrochloride
Drug ID BADD_D01481
Description An anthracenedione-derived antineoplastic agent.
Indications and Usage For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Marketing Status approved; investigational
ATC Code L01DB07
DrugBank ID DB01204
KEGG ID D02166
MeSH ID D008942
PubChem ID 51082
TTD Drug ID D0R3JB
NDC Product Code 58598-0005; 63323-132
UNII U6USW86RD0
Synonyms Mitoxantrone | Mitozantrone | DHAQ | NSC-279836 | NSC 279836 | NSC279836 | NSC-287836 | NSC 287836 | NSC287836 | NSC-299195 | NSC 299195 | NSC299195 | NSC-301739 | NSC 301739 | NSC301739 | NSC-301739D | NSC 301739D | NSC301739D | Mitroxone | Pralifan | CL-232325 | CL 232325 | CL232325 | Mitoxantrone Acetate | Acetate, Mitoxantrone | Mitoxantrone Hydrochloride | Hydrochloride, Mitoxantrone | Novantrone | Ralenova | Novantron | Onkotrone
Chemical Information
Molecular Formula C22H30Cl2N4O6
CAS Registry Number 70476-82-3
SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site extravasation08.02.03.002; 12.07.03.002--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.001--Not Available
Lung disorder22.02.07.001--Not Available
Lymphocyte count decreased13.01.06.006--
Malaise08.01.01.003--
Menstrual disorder21.01.01.004--Not Available
Mucosal inflammation08.01.06.002--Not Available
Myalgia15.05.02.001--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nail disorder23.02.05.002--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Platelet count13.01.04.011--Not Available
Platelet count abnormal13.01.04.005--Not Available
Platelet count decreased13.01.04.001--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Proteinuria20.02.01.011--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal disorder20.01.02.002--Not Available
Renal failure20.01.03.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
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