| Drug Name |
Mupirocin |
| Drug ID |
BADD_D01504 |
| Description |
Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism _Pseudomonas fluorescens_, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative bacteria _in vitro_.[L10580] It primarily works by inhibiting bacterial protein synthesis. Due to its unique mode of action of inhibiting the activity of bacterial isoleucyl-tRNA synthetase, mupirocin does not demonstrate cross-resistance with other classes of antimicrobial agents, giving it a therapeutic advantage.[L10580] It is available in topical formulations only due to extensive systemic metabolism[A178531] and is used in the treatment of impetigo caused by _Staphylococcus aureus_ and _Streptococcus pyogenes_ and traumatic skin lesions due to secondary skin infections caused by _S. aureus_ and _S. pyogenes_. There is also some clinical evidence that suggests the potential role of mupirocin in eradicating nasal carriage of Staphylococci when administered intranasally.[A178531,A178591] Mupirocin is commonly marketed under the brand name Bactroban. |
| Indications and Usage |
Indicated for the treatment of impetigo and secondary skin infections, leading to traumatic skin lesions, due to _Staphylococcus aureus_ and _Streptococcus pyogenes_.[L10580] |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
D06AX09; R01AX06 |
| DrugBank ID |
DB00410
|
| KEGG ID |
D01076
|
| MeSH ID |
D016712
|
| PubChem ID |
446596
|
| TTD Drug ID |
D03JSJ
|
| NDC Product Code |
51552-1194; 51927-0010; 68254-2504; 68462-560; 51846-1017; 63187-151; 80425-0254; 81033-020; 21922-029; 68462-180; 70518-1808; 65897-2003; 68254-0010; 0093-1010; 50268-568; 62332-624; 53002-9853; 63187-261; 69238-2029; 76420-128; 45865-722; 63629-9439; 68462-564; 68788-9891; 70166-017; 80425-0246; 62991-2701; 70518-2344; 0904-7284; 0168-0352; 45802-018; 51672-1312; 53002-9850; 63187-015; 63629-8687; 68071-4111; 68788-7993; 38779-2545; 51927-0296; 65897-1003; 49999-644; 53002-9851; 63187-525; 63629-9440; 45802-112; 50090-1587 |
| UNII |
D0GX863OA5
|
| Synonyms |
Mupirocin | Pseudomonic Acid A | Mupirocin Calcium | Mupirocin, Sodium Salt | Mupirocin, Lithium Salt | BRL-4910A | BRL 4910A | BRL4910A | Mupirocin, 14C-Labeled | 14C-Labeled Mupirocin | Mupirocin, 14C Labeled | Mupirocin, Calcium Salt (2:1) | Mupirocin, Calcium Salt (2:1), Dihydrate | Pseudomonic Acid | Bactroban |
