Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin
Drug ID BADD_D01515
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status approved; investigational
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D08242
MeSH ID D009254
PubChem ID 8982
TTD Drug ID D0A0JH
NDC Product Code 44567-223; 0338-1019; 44567-221; 63323-330; 0338-1017; 44567-222
UNII 4CNZ27M7RV
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H22N2O5S
CAS Registry Number 147-52-4
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic failure09.01.03.0020.000049%
Hepatitis cholestatic09.01.01.0020.000097%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.000219%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.000049%
Hyperkalaemia14.05.03.0010.000049%
Hypersensitivity10.01.03.0030.000180%
Hypersensitivity vasculitis24.12.04.013; 23.06.02.005; 10.02.02.017; 01.01.04.0080.000097%Not Available
Hypokalaemia14.05.03.0020.000262%
Hypotension24.06.03.0020.000097%
Hypothyroidism14.11.01.012; 05.02.03.0010.000049%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000146%Not Available
Jaundice cholestatic09.01.01.0050.000049%Not Available
Laryngeal oedema10.01.05.003; 23.04.01.005; 22.04.02.001--
Laryngospasm22.04.02.002--
Leukocytosis01.02.01.0020.000049%
Liver function test abnormal13.03.04.030--Not Available
Local reaction08.01.03.012--Not Available
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.0010.000204%
Necrosis24.04.02.006; 08.03.03.001--Not Available
Nephritis20.05.02.0010.000122%Not Available
Nephropathy20.05.03.001--Not Available
Neurotoxicity17.02.10.002; 12.03.01.011--Not Available
Neutropenia01.02.03.0040.000049%Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.000228%
The 2th Page    First    Pre   2 3 4    Next   Last    Total 4 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene