Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Neostigmine methylsulfate
Drug ID BADD_D01554
Description A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Indications and Usage Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
Marketing Status approved; vet_approved
ATC Code S01EB06; N07AA01
DrugBank ID DB01400
KEGG ID D00998
MeSH ID D009388
PubChem ID 5824
TTD Drug ID D08USJ
NDC Product Code 0641-6150; 75834-150; 23155-517; 65145-111; 68083-383; 71872-7143; 0641-6264; 38779-1851; 59651-243; 75834-149; 14445-015; 14593-903; 47621-305; 51662-1557; 63323-413; 68083-384; 70069-805; 70594-069; 71839-106; 72572-460; 0404-9925; 71288-501; 42023-188; 51754-1240; 52584-057; 70069-806; 70700-172; 0548-9601; 76045-383; 10695-033; 14501-0022; 23155-518; 65145-112; 70594-072; 71872-7271; 0641-6149; 0641-6265; 14778-0707; 42023-189; 51754-1210; 63323-415; 70121-1478; 72572-461; 0641-6240; 76045-214; 51927-0191; 66064-1020; 14445-414; 25021-611; 43598-945; 65219-811; 71872-7016; 72572-462; 45941-3053; 31722-995; 51754-1220; 70121-1479; 70516-0161; 25021-610; 70700-171; 0548-9602; 71288-500; 71839-105; 14445-413; 31722-994
UNII 98IMH7M386
Synonyms Neostigmine | Synstigmin | Proserine | Prozerin | Polstigmine | Neostigmine Bromide | Bromide, Neostigmine | Syntostigmine | Neostigmine Methylsulfate | Methylsulfate, Neostigmine | Prostigmine | Prostigmin
Chemical Information
Molecular Formula C13H22N2O6S
CAS Registry Number 51-60-5
SMILES CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.COS(=O)(=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Chromatopsia06.02.05.001--Not Available
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dysarthria19.19.03.001; 17.02.08.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram abnormal13.14.05.001--Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Loss of consciousness17.02.04.004--Not Available
Miosis17.02.11.002; 06.05.03.003--Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nodal rhythm02.03.03.021--Not Available
Pollakiuria20.02.02.007--
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
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