Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nepafenac
Drug ID BADD_D01555
Description Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indications and Usage For the treatment of pain and inflammation associated with cataract surgery.
Marketing Status approved; investigational
ATC Code S01BC10
DrugBank ID DB06802
KEGG ID D05143
MeSH ID C414203
PubChem ID 151075
TTD Drug ID D02IHW
NDC Product Code 73309-311; 53296-0099; 64181-0019; 42571-353; 58567-104; 86036-006; 0078-0743; 69988-0005; 0078-0778
UNII 0J9L7J6V8C
Synonyms nepafenac | 2-amino-3-benzoylbenzeneacetamide | Nevanac
Chemical Information
Molecular Formula C15H14N2O2
CAS Registry Number 78281-72-8
SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema23.03.06.0010.000588%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.0030.000294%Not Available
Eye discharge06.04.05.0010.002941%Not Available
Eye disorder06.08.03.0010.000647%Not Available
Eye inflammation06.04.05.0020.001500%Not Available
Eye irritation06.04.05.0030.003940%Not Available
Eye pain06.08.03.0020.006116%
Eye swelling06.08.03.0030.002294%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000588%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.0020.000647%Not Available
Feeling abnormal08.01.09.0140.001441%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Glaucoma06.03.01.0020.000294%
Headache17.14.01.001--
Hypersensitivity10.01.03.0030.001294%
Hypertension24.08.02.001--
Immune system disorder10.02.01.001--Not Available
Impaired healing08.03.02.001--Not Available
Intraocular pressure increased13.07.04.002--Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Keratitis06.04.02.002--
Lacrimation decreased06.08.02.007--Not Available
Lacrimation increased06.08.02.0040.000941%
Lenticular opacities06.06.01.003--Not Available
Macular oedema06.04.06.0050.000882%Not Available
Malaise08.01.01.0030.001647%
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Night blindness06.02.10.010; 14.12.03.0010.000647%
Ocular hyperaemia06.04.05.0040.004323%Not Available
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