Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitric oxide
Drug ID BADD_D01574
Description Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
Indications and Usage For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Marketing Status approved
ATC Code R07AX01
DrugBank ID DB00435
KEGG ID D00074
MeSH ID D009569
PubChem ID 145068
TTD Drug ID D0A5FM
NDC Product Code 64693-002; 83202-8251; 72385-001; 72385-002; 80519-301; 83202-2278; 83202-6645; 83202-2149; 83202-5147; 83202-6658; 83202-7712; 83202-1857; 83202-6487; 83202-6518; 83202-6931; 83202-7715; 83202-6841; 64693-003; 83202-2952
UNII 31C4KY9ESH
Synonyms Nitric Oxide | Oxide, Nitric | Nitrogen Monoxide | Monoxide, Nitrogen | Nitric Oxide, Endothelium-Derived | Endothelium-Derived Nitric Oxide | Nitric Oxide, Endothelium Derived | Endogenous Nitrate Vasodilator | Nitrate Vasodilator, Endogenous | Vasodilator, Endogenous Nitrate | Mononitrogen Monoxide | Monoxide, Mononitrogen
Chemical Information
Molecular Formula NO
CAS Registry Number 10102-43-9
SMILES [N]=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myocardial infarction24.04.04.001; 02.02.02.001-Not Available
Acute respiratory distress syndrome24.03.02.034; 10.02.01.067; 22.01.03.001-
Acute respiratory failure22.02.06.001; 14.01.04.004-Not Available
Aortic dissection24.02.03.002-Not Available
Atelectasis22.01.02.001--
Bradycardia02.03.02.002-Not Available
Cardiac arrest02.03.04.001-
Cardiac failure02.05.01.001-
Cardio-respiratory arrest22.02.06.007; 02.03.04.002-Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003-Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001-Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Coagulopathy01.01.02.001-Not Available
Condition aggravated08.01.03.004-Not Available
Death08.04.01.001-
Death neonatal18.04.01.002; 08.04.01.002-
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002-
Dry throat22.12.03.005; 07.06.01.005--Not Available
Dyspnoea02.11.05.003; 22.02.01.004--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Haemoglobin13.01.05.018--Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Headache17.14.01.001--
Hypotension24.06.03.002-
Hypoxia22.02.02.003-
Interstitial lung disease22.01.02.003; 10.02.01.033-Not Available
Intracranial pressure increased17.07.02.002-Not Available
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ADReCS-Target
Drug Name ADR Term Target
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