Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nortriptyline hydrochloride
Drug ID BADD_D01589
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).[L11878] Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.[A191083,L11878]
Marketing Status approved
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D00816
MeSH ID D009661
PubChem ID 441358
TTD Drug ID D04WFD
NDC Product Code 51927-0128; 50090-0507; 50090-1323; 50268-604; 51672-4004; 60760-811; 0406-9913; 70518-3485; 70771-1612; 70771-1613; 50090-0537; 55700-501; 60760-508; 61919-590; 63187-396; 63187-798; 51927-2175; 0121-0678; 51672-4002; 68788-7216; 68788-8158; 70518-0708; 70518-3543; 70710-1155; 71205-254; 71335-0155; 60687-265; 70518-0702; 71205-770; 71335-2199; 49452-4858; 54154-007; 64330-018; 50268-603; 60687-281; 60687-293; 63187-715; 63187-759; 0406-9912; 70518-0741; 70518-1522; 70710-1154; 70771-1615; 72189-177; 62991-2905; 71554-011; 43063-897; 51672-4001; 51862-946; 0406-9910; 0406-9911; 68788-9830; 70710-1153; 80425-0299; 17337-0534; 66577-025; 0093-0810; 0093-0812; 51655-507; 70710-1156; 70771-1614; 71335-0083; 0093-0813; 43063-722; 61919-353; 71335-0426; 71335-1552; 71335-1726; 71335-1743; 50268-605; 51862-945; 51862-947; 60760-401; 63629-3204; 68071-3211; 68788-8202; 71335-1773; 46438-0049; 63187-809; 70934-954; 71335-0065; 0093-0811; 51672-4003; 51862-016; 51862-948; 55700-668; 58118-4002
UNII 00FN6IH15D
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H22ClN
CAS Registry Number 894-71-3
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Purpura23.06.01.004; 01.01.04.003; 24.07.06.005--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Stomatitis07.05.06.005--
Tachycardia02.03.02.007--Not Available
Testicular swelling21.13.01.003--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue discolouration07.14.02.006--Not Available
Tongue oedema07.14.02.007; 23.04.01.009; 10.01.05.008--Not Available
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Urinary tract malformation20.08.03.002; 03.06.02.003--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.002--
Bone marrow failure01.03.03.005--
Cross sensitivity reaction10.01.01.036--Not Available
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