Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxymetholone
Drug ID BADD_D01647
Description Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth in malnourished or underdeveloped patients. Anabolic-androgenic steroids (AAS), such as oxymetholone, have been abused by bodybuilders and athletes. The uncontrolled misuse of oxymetholone can lead to a large variety of detrimental effects, the most often reported of which are cardiovascular events. In 2009, no producers of oxymetholone were identified worldwide (SRI 2009), but it was available from 14 suppliers, including 8 U.S. suppliers (ChemSources 2009).
Indications and Usage Indicated in the treatment of anemias caused by deficient red cell production. Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond. Oxymetholone should not replace other supportive measures such as transfusion, correction of iron, folic acid, vitamin B12 or pyridoxine deficiency, antibacterial therapy and the appropriate use of corticosteroids.
Marketing Status approved; illicit
ATC Code A14AA05
DrugBank ID DB06412
KEGG ID D00490
MeSH ID D010110
PubChem ID 5281034
TTD Drug ID D0Q6NZ
NDC Product Code 49803-008; 51552-1592; 63275-9870; 30007-832
UNII L76T0ZCA8K
Synonyms Oxymetholone | Oxymethalone | Hydroxymetholone | Oxymetholone, (5 alpha,17 alpha)-Isomer | Oxymetholone, (17 beta)-Isomer | Anadrol | Anapolon 50
Chemical Information
Molecular Formula C21H32O3
CAS Registry Number 434-07-1
SMILES CC12CCC3C(C1CCC2(C)O)CCC4C3(CC(=CO)C(=O)C4)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acne23.02.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Aspartate aminotransferase increased13.03.04.011--
Azoospermia21.03.03.001--
Bladder irritation20.02.02.020--Not Available
Blood bilirubin increased13.03.04.018--
Blood creatine increased13.13.01.001--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Bromosulphthalein test abnormal13.03.04.021--Not Available
Chills08.01.09.001; 15.05.03.016--
Clitoral engorgement21.08.02.006--Not Available
Death08.04.01.001--
Diarrhoea07.02.01.001--
Dysphonia22.12.03.006; 19.19.03.002; 17.02.08.004--
Enlarged clitoris21.08.02.001; 05.05.01.004--Not Available
Epididymitis21.09.02.001; 11.01.19.005--Not Available
Epiphyses premature fusion05.05.03.002; 15.02.02.001--Not Available
Erection increased21.03.01.004; 19.08.04.002--Not Available
Glucose tolerance decreased13.02.02.004--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemoglobin13.01.05.018--Not Available
Hepatic necrosis09.01.07.002--
Hepatic neoplasm16.07.03.001; 09.04.03.001--Not Available
High density lipoprotein decreased13.12.01.003--Not Available
Hirsutism23.02.04.001; 05.05.01.005--
Insomnia19.02.01.002; 17.15.03.002--
Iron deficiency anaemia14.13.02.001; 01.03.01.002--Not Available
Irritability08.01.03.011; 19.04.02.013--
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