Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pamidronic acid
Drug ID BADD_D01662
Description Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Indications and Usage Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Marketing Status approved
ATC Code M05BA03
DrugBank ID DB00282
KEGG ID D07281
MeSH ID D000077268
PubChem ID 4674
TTD Drug ID D0BF8G
NDC Product Code 53104-7611; 50711-0003
UNII OYY3447OMC
Synonyms Pamidronate | Amino-1-hydroxypropane-1,1-diphosphonate | Amino 1 hydroxypropane 1,1 diphosphonate | AHPrBP | Aminopropanehydroxydiphosphonate | Amidronate | (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate | Aminohydroxypropylidene Diphosphonate | 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid | 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid | Pamidronic Acid | Pamidronate Monosodium | Pamidronate Calcium | Pamidronate Disodium | Aredia
Chemical Information
Molecular Formula C3H11NO7P2
CAS Registry Number 40391-99-9
SMILES C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute lymphocytic leukaemia16.01.01.001; 01.10.01.001--Not Available
Acute respiratory distress syndrome24.03.02.034; 10.02.01.067; 22.01.03.001--
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.0020.000189%
Arthralgia15.01.02.0010.000126%
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.0010.000126%Not Available
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Blood creatinine abnormal13.13.01.002--Not Available
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.000252%Not Available
Bone pain15.02.01.0010.000126%
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure02.05.01.0010.000126%
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
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