Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pamidronic acid
Drug ID BADD_D01662
Description Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Indications and Usage Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Marketing Status approved
ATC Code M05BA03
DrugBank ID DB00282
KEGG ID D07281
MeSH ID D000077268
PubChem ID 4674
TTD Drug ID D0BF8G
NDC Product Code 53104-7611; 50711-0003
UNII OYY3447OMC
Synonyms Pamidronate | Amino-1-hydroxypropane-1,1-diphosphonate | Amino 1 hydroxypropane 1,1 diphosphonate | AHPrBP | Aminopropanehydroxydiphosphonate | Amidronate | (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate | Aminohydroxypropylidene Diphosphonate | 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid | 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid | Pamidronic Acid | Pamidronate Monosodium | Pamidronate Calcium | Pamidronate Disodium | Aredia
Chemical Information
Molecular Formula C3H11NO7P2
CAS Registry Number 40391-99-9
SMILES C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.010--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction08.02.03.014; 12.07.03.015--
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease10.02.01.033; 22.01.02.003--Not Available
Iridocyclitis06.04.03.001--Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Left ventricular failure02.05.02.001--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000189%
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.001--Not Available
Lung infiltration22.01.02.0040.000126%Not Available
Lymphoedema24.09.01.001; 01.09.01.006--
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.0030.000189%
Muscle spasms15.05.03.004--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nephrocalcinosis20.04.01.0010.000126%Not Available
Nephropathy20.05.03.001--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 8 Pages