Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pamidronic acid
Drug ID BADD_D01662
Description Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Indications and Usage Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Marketing Status approved
ATC Code M05BA03
DrugBank ID DB00282
KEGG ID D07281
MeSH ID D000077268
PubChem ID 4674
TTD Drug ID D0BF8G
NDC Product Code 53104-7611; 50711-0003
UNII OYY3447OMC
Synonyms Pamidronate | Amino-1-hydroxypropane-1,1-diphosphonate | Amino 1 hydroxypropane 1,1 diphosphonate | AHPrBP | Aminopropanehydroxydiphosphonate | Amidronate | (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate | Aminohydroxypropylidene Diphosphonate | 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid | 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid | Pamidronic Acid | Pamidronate Monosodium | Pamidronate Calcium | Pamidronate Disodium | Aredia
Chemical Information
Molecular Formula C3H11NO7P2
CAS Registry Number 40391-99-9
SMILES C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Uveitis10.02.01.023; 06.04.03.003--
Vein disorder24.03.02.0150.000126%Not Available
Venous thrombosis24.01.01.0080.000126%Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.0030.000315%
Xanthopsia06.02.05.002--Not Available
Tubulointerstitial nephritis20.05.02.002--Not Available
Mobility decreased08.01.03.030; 15.03.05.023; 17.02.05.018--Not Available
Poor venous access24.03.02.0170.000126%Not Available
Emotional distress19.04.02.0080.000189%Not Available
Deep vein thrombosis24.01.02.0030.000126%Not Available
Malignant neoplasm progression16.16.01.005--Not Available
Eye pruritus06.04.05.006--Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Infusion site reaction12.07.05.006; 08.02.05.005--Not Available
Haemorrhage24.07.01.002--Not Available
Angiopathy24.03.02.007--Not Available
Induration08.01.03.020--Not Available
Neurological symptom17.02.05.010--Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Inflammation10.02.01.089; 08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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