Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pamidronic acid
Drug ID BADD_D01662
Description Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Indications and Usage Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Marketing Status approved
ATC Code M05BA03
DrugBank ID DB00282
KEGG ID D07281
MeSH ID D000077268
PubChem ID 4674
TTD Drug ID D0BF8G
NDC Product Code 53104-7611; 50711-0003
UNII OYY3447OMC
Synonyms Pamidronate | Amino-1-hydroxypropane-1,1-diphosphonate | Amino 1 hydroxypropane 1,1 diphosphonate | AHPrBP | Aminopropanehydroxydiphosphonate | Amidronate | (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate | Aminohydroxypropylidene Diphosphonate | 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid | 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid | Pamidronic Acid | Pamidronate Monosodium | Pamidronate Calcium | Pamidronate Disodium | Aredia
Chemical Information
Molecular Formula C3H11NO7P2
CAS Registry Number 40391-99-9
SMILES C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ill-defined disorder08.01.03.049--Not Available
Blood disorder01.05.01.004--Not Available
Chondrocalcinosis14.04.01.017; 15.01.06.0060.000126%Not Available
Disease recurrence08.01.03.050--Not Available
Drug intolerance08.06.01.0130.000340%Not Available
Psychotic disorder19.03.01.002--
Metastasis16.22.01.001--Not Available
Renal impairment20.01.03.0100.000189%Not Available
Cholecystitis infective11.01.18.002; 09.03.01.006--
Hypophagia07.01.06.010; 19.09.01.004; 14.03.01.0060.000252%Not Available
Osteonecrosis of jaw24.04.05.005; 15.02.04.0100.002141%
Infusion site thrombosis24.01.01.022; 12.07.05.007; 08.02.05.0060.000189%Not Available
Oral disorder07.05.01.005--Not Available
Focal segmental glomerulosclerosis20.05.01.0030.000126%Not Available
Acute kidney injury20.01.03.016--
Langerhans' cell histiocytosis01.13.04.003; 15.09.03.008; 09.01.08.018; 22.01.01.016; 16.21.04.003--Not Available
Candida infection11.03.03.021--
Bone cancer16.29.02.002; 15.09.03.012--Not Available
Metastases to bone15.09.03.006; 16.22.02.005--Not Available
Bone formation decreased15.02.04.0280.000189%Not Available
Deformity08.01.03.0220.000315%Not Available
Weight bearing difficulty15.03.05.0340.000126%Not Available
Metastases to pelvis21.07.04.008; 16.22.02.021--Not Available
Drug ineffective for unapproved indication12.09.02.002; 08.06.01.0380.001033%Not Available
Illness08.01.03.091--Not Available
Joint noise15.01.02.012--Not Available
Mineral metabolism disorder14.13.04.0020.000189%Not Available
Product administration error12.09.03.003--Not Available
Superficial vein thrombosis24.01.02.0160.000126%Not Available
Therapy non-responder08.06.01.0630.000277%Not Available
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