Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Papaverine
Drug ID BADD_D01670
Description An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Indications and Usage For the treatment of impotence and vasospasms.
Marketing Status approved; investigational
ATC Code A03AD01; G04BE02
DrugBank ID DB01113
KEGG ID D07425
MeSH ID D010208
PubChem ID 4680
TTD Drug ID D0NJ3V
NDC Product Code Not Available
UNII DAA13NKG2Q
Synonyms Papaverine | Pavatym | Pavabid | Cerespan | Papaverine Hydrochloride | Hydrochloride, Papaverine
Chemical Information
Molecular Formula C20H21NO4
CAS Registry Number 58-74-2
SMILES COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Malaise08.01.01.003--
Nausea07.01.07.001--
Rash23.03.13.001--Not Available
Sedation17.02.04.005--Not Available
Vertigo04.04.01.003; 17.02.12.002--
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049--Not Available
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