| Pharmaceutical Information |
| Drug Name |
Parecoxib |
| Drug ID |
BADD_D01674 |
| Description |
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005. |
| Indications and Usage |
Used for short term perioperative pain control. |
| Marketing Status |
approved |
| ATC Code |
M01AH04 |
| DrugBank ID |
DB08439
|
| KEGG ID |
D03716
|
| MeSH ID |
C409945
|
| PubChem ID |
119828
|
| TTD Drug ID |
D05UWI
|
| NDC Product Code |
Not Available |
| UNII |
9TUW81Y3CE
|
| Synonyms |
parecoxib | N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide | N-(((Me-P)-P)S)P | parecoxib sodium | N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, sodium salt | Dynastat |
|
| Chemical Information |
| Molecular Formula |
C19H18N2O4S |
| CAS Registry Number |
198470-84-7 |
| SMILES |
CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Acute kidney injury | 20.01.03.016 | - | - | |
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