| Drug Name |
Paroxetine hydrochloride |
| Drug ID |
BADD_D01680 |
| Description |
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters.[A31914] Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.[A31914] The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742] |
| Indications and Usage |
Paroxetine is indicated for the management of depression, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder.[L3358] One form of paroxetine, commercially known as Brisdelle, is used to manage mild to moderate vasomotor symptoms of menopause.[L7703] Off-label, paroxetine may be used for the treatment of premature ejaculation or irritable bowel syndrome (IBS).[A1093,A181754,A181904] |
| Marketing Status |
approved; investigational |
| ATC Code |
N06AB05 |
| DrugBank ID |
DB00715
|
| KEGG ID |
D05374
|
| MeSH ID |
D017374
|
| PubChem ID |
62878
|
| TTD Drug ID |
D06GDY
|
| NDC Product Code |
65862-155; 16714-184; 49999-632; 65841-098; 65862-157; 67544-492; 68084-045; 68084-046; 71335-9650; 60505-0402; 60505-1317; 68084-044; 68788-0797; 0904-5676; 60505-1318; 60505-4520; 69584-673; 60429-735; 60505-4519; 69584-671; 16714-183; 60505-4377; 60505-4379; 68071-4283; 68788-9074; 69584-672; 71335-1205; 65862-154; 43353-845; 43353-994; 60429-736; 65841-099; 65841-601; 65862-156; 61187-005; 16714-182; 60429-737; 60505-0083; 60505-1316; 60505-4517; 60505-4518; 70518-0993; 70518-2871; 55154-7999; 60429-734; 60505-0084; 60505-0097; 62175-470; 62175-471; 67544-317; 62175-472; 63629-8527; 0904-5677; 16714-181; 60505-0101; 60505-4378; 65841-097; 68084-047; 69584-674; 70518-1460; 70518-2118 |
| UNII |
X2ELS050D8
|
| Synonyms |
Paroxetine | Aropax | BRL-29060 | BRL 29060 | BRL29060 | FG-7051 | FG 7051 | FG7051 | Paroxetine Acetate | Seroxat | Paroxetine Hydrochloride Anhydrous | Paroxetine Maleate | Paroxetine, cis-(+)-Isomer | Paroxetine, cis-(-)-Isomer | Paroxetine, trans-(+)-Isomer | Paxil | Paroxetine Hydrochloride Hemihydrate | Paroxetine Hydrochloride, Hemihydrate | Paroxetine Hydrochloride |
