Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pasireotide diaspartate
Drug ID BADD_D01685
Description Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.
Indications and Usage For the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery has not been curative or is not an option.
Marketing Status approved
ATC Code H01CB05
DrugBank ID DB06663
KEGG ID D10497
MeSH ID C517782
PubChem ID 70788982
TTD Drug ID D0TV0C
NDC Product Code 71161-128; 71161-129; 55292-133; 55292-142; 55292-143; 55292-139; 55292-141; 71161-130; 71161-127; 71161-126; 55292-140; 55292-131; 55292-132
UNII I4P76SY3N4
Synonyms pasireotide | cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-d-tryptophyl-L-lysyl-4-o-benzyl-L-tyrosyl-L-phenylalanyl-) | SOM-230 | SOM 230 | SOM230
Chemical Information
Molecular Formula C66H80N12O17
CAS Registry Number 820232-50-6
SMILES C1C(CN2C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4 )OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN.C(C(C(=O)O)N)C(=O )O.C(C(C(=O)O)N)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Addison's disease14.11.01.025; 10.04.08.008; 05.01.02.006--Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.001--
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood glucose increased13.02.02.002--Not Available
Cholelithiasis09.03.01.002--Not Available
Constipation07.02.02.001--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry skin23.03.03.001--
Electrocardiogram QT prolonged13.14.05.004--
Fatigue08.01.01.002--
Gamma-glutamyltransferase increased13.03.04.024--
Gastrointestinal pain07.01.05.005--
Glycosylated haemoglobin increased13.02.02.005--Not Available
Headache17.14.01.001--
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypertension24.08.02.001--
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