Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pegaptanib
Drug ID BADD_D01690
Description Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Indications and Usage For the treatment of neovascular (wet) age-related macular degeneration.
Marketing Status approved; investigational
ATC Code S01LA03
DrugBank ID DB04895
KEGG ID D05386
MeSH ID C495058
PubChem ID 56603655
TTD Drug ID D0UF9W
NDC Product Code Not Available
UNII 2H1PA8H1EN
Synonyms pegaptanib | Macugen | pegaptanib sodium
Chemical Information
Molecular Formula C22H44N3O10P
CAS Registry Number 222716-86-1
SMILES COCCOC(=O)NCCCCC(C(=O)NCCCCCCCOP(=O)(C)O)NC(=O)OCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal sensation in eye06.01.01.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Aortic aneurysm24.02.03.001--Not Available
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.002--Not Available
Back pain15.03.04.005--
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cataract06.06.01.001--
Cataract traumatic12.01.04.008; 06.11.01.002--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chalazion06.04.04.002--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.003--Not Available
Chills15.05.03.016; 08.01.09.001--
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Conjunctival oedema06.04.01.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Conjunctivitis allergic10.01.04.002; 06.04.01.003--Not Available
Corneal abrasion12.01.04.001; 06.11.03.001--Not Available
Corneal deposits06.06.03.002--Not Available
Corneal dystrophy06.13.03.001; 03.01.06.001--Not Available
Corneal epithelium defect06.06.03.012--Not Available
Corneal erosion06.06.03.003--Not Available
Corneal oedema06.04.02.001--Not Available
Deafness04.02.01.001--Not Available
Deposit eye06.09.04.005--Not Available
Dermatitis23.03.04.002--Not Available
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