Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pegaptanib
Drug ID BADD_D01690
Description Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Indications and Usage For the treatment of neovascular (wet) age-related macular degeneration.
Marketing Status approved; investigational
ATC Code S01LA03
DrugBank ID DB04895
KEGG ID D05386
MeSH ID C495058
PubChem ID 56603655
TTD Drug ID D0UF9W
NDC Product Code Not Available
UNII 2H1PA8H1EN
Synonyms pegaptanib | Macugen | pegaptanib sodium
Chemical Information
Molecular Formula C22H44N3O10P
CAS Registry Number 222716-86-1
SMILES COCCOC(=O)NCCCCC(C(=O)NCCCCCCCOP(=O)(C)O)NC(=O)OCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retinal exudates06.10.02.003; 14.07.01.007; 05.07.01.007; 24.03.07.007--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Retinal oedema24.03.07.006; 06.04.06.007--Not Available
Retinal scar06.09.03.017; 12.01.04.021--Not Available
Retinal tear12.01.04.014; 06.09.03.010--
Retinal vein occlusion24.01.07.006; 06.10.01.010--Not Available
Rhinorrhoea22.12.03.021--
Skin disorder23.03.03.007--Not Available
Tenderness08.01.08.005--Not Available
Transient ischaemic attack24.04.06.005; 17.08.04.001--
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity reduced06.02.10.012; 17.17.01.011--
Visual impairment06.02.10.013--Not Available
Vitreous detachment12.01.04.005; 06.09.01.002--Not Available
Vitreous disorder06.08.03.006--Not Available
Vitreous floaters06.09.01.005--
Vitreous haemorrhage24.07.05.005; 06.10.03.001--
Vitreous opacities06.09.01.007--Not Available
Vitreous prolapse12.01.04.022; 06.09.01.009--Not Available
Vomiting07.01.07.003--
Hypoacusis04.02.01.006--
Carotid artery occlusion24.04.06.008; 17.08.01.012--Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Conjunctival hyperaemia06.04.01.004--Not Available
Eyelids pruritus23.03.12.005; 06.08.03.007--Not Available
Eye pruritus06.04.05.006--Not Available
Ocular discomfort06.08.03.008--Not Available
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