| Pharmaceutical Information |
| Drug Name |
Penbutolol sulfate |
| Drug ID |
BADD_D01707 |
| Description |
Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects. This binding characteristic of penbutolol is being investigated for its implications in Antidepressant Therapy. Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity. |
| Indications and Usage |
Penbutolol is indicated in the treatment of mild to moderate arterial hypertension. It may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity. |
| Marketing Status |
approved; investigational |
| ATC Code |
C07AA23 |
| DrugBank ID |
DB01359
|
| KEGG ID |
D00602
|
| MeSH ID |
D010394
|
| PubChem ID |
38010
|
| TTD Drug ID |
D0W8SB
|
| NDC Product Code |
48954-699 |
| UNII |
US71433228
|
| Synonyms |
Penbutolol | Penbutolol Sulfate | Sulfate, Penbutolol | Penbutolol Sulfate (2:1) | Betapressin | Hoe-893d | Hoe 893d | Hoe893d |
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| Chemical Information |
| Molecular Formula |
C36H60N2O8S |
| CAS Registry Number |
38363-32-5 |
| SMILES |
CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O.CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O)
O |
| Chemical Structure |
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| ADRs Induced by Drug |
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