| Pharmaceutical Information |
| Drug Name |
Pentetate calcium trisodium |
| Drug ID |
BADD_D01721 |
| Description |
Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment of internal contamination by transuranics.[A32501] It is currently considered, in all the dosage forms, as a member of the list of approved inactive ingredients for drug products by the FDA.[L2242] DPTA was developed by the pharmaceutical company CIS US and FDA approved on April 14, 2004.[L1469] |
| Indications and Usage |
DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides.[A32501] It is FDA approved for the treatment of individuals with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.[L2243]
Due to the pharmacokinetic elimination by the kidneys, pentetic acid conjugated with technetium Tc-99m is being used clinically to estimate physiological parameters such as glomerular filtration rat and effective renal plasma flow.[T168] |
| Marketing Status |
approved |
| ATC Code |
Not Available |
| DrugBank ID |
DB14007
|
| KEGG ID |
D05419
|
| MeSH ID |
D004369
|
| PubChem ID |
25513
|
| TTD Drug ID |
D09NFN
|
| NDC Product Code |
70651-001 |
| UNII |
G79YN26H5B
|
| Synonyms |
Pentetic Acid | Penthanil | DTPA | Pentaind | DETAPAC | Diethylenetriamine Pentaacetic Acid | Pentaacetic Acid, Diethylenetriamine | Mn-Dtpa | Zinc-DTPA | Zinc DTPA | Ca-DTPA | CaDTPA | Pentetate Calcium Trisodium | CaNa-DTPA | Calcium Trisodium Pentetate | Pentetate, Calcium Trisodium | Pentetate Zinc Trisodium | Pentetates | Sn-DTPA | Indium-DTPA | Indium DTPA | Pentacine | Pentacin |
|
| Chemical Information |
| Molecular Formula |
C14H18CaN3Na3O10 |
| CAS Registry Number |
12111-24-9 |
| SMILES |
C(CN(CC(=O)[O-])CC(=O)[O-])N(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[N
a+].[Ca+2] |
| Chemical Structure |
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| ADRs Induced by Drug |
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