| Pharmaceutical Information |
| Drug Name |
Perindopril |
| Drug ID |
BADD_D01739 |
| Description |
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease. |
| Indications and Usage |
For the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease. |
| Marketing Status |
approved |
| ATC Code |
C09AA04 |
| DrugBank ID |
DB00790
|
| KEGG ID |
D03753
|
| MeSH ID |
D020913
|
| PubChem ID |
107807
|
| TTD Drug ID |
D03KYG
|
| NDC Product Code |
65977-0019 |
| UNII |
Y5GMK36KGY
|
| Synonyms |
Perindopril | Pirindopril | S-9490 | S 9490 | S9490 | S 9490-3 | S 9490 3 | S 94903 | Perindopril Erbumine | Erbumine, Perindopril | Perstarium |
|
| Chemical Information |
| Molecular Formula |
C19H32N2O5 |
| CAS Registry Number |
82834-16-0 |
| SMILES |
CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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