Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Phenobarbital
Drug ID BADD_D01752
Description A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Indications and Usage For the treatment of all types of seizures except absence seizures.
Marketing Status approved; investigational
ATC Code N03AA02
DrugBank ID DB01174
KEGG ID D00506
MeSH ID D010634
PubChem ID 4763
TTD Drug ID D0Y7RW
NDC Product Code 75826-142; 13517-626; 13517-628; 13517-758; 0121-0531; 51293-692; 54932-501; 63629-2399; 69367-214; 70752-163; 71205-892; 16571-673; 0143-1455; 0143-1458; 54932-207; 58118-0626; 60687-448; 62135-406; 62135-412; 63629-1033; 63629-2043; 63629-2045; 63629-2400; 70752-157; 70752-165; 70752-168; 71205-848; 72162-1584; 76003-0894; 13517-691; 16571-671; 0143-1500; 43063-953; 51293-693; 60687-671; 62135-405; 62135-410; 63629-1037; 63629-2402; 69367-172; 70518-2405; 70518-2418; 70518-3469; 70518-3470; 70752-164; 71205-851; 71205-891; 0603-1508; 0603-5165; 58118-1110; 64380-166; 70518-0911; 71205-890; 16571-669; 51293-691; 63629-1034; 63629-1038; 71205-845; 71205-846; 0603-5166; 75826-139; 75826-140; 50095-001; 66064-2001; 13517-625; 13517-627; 13517-693; 13517-757; 16571-672; 51293-627; 63629-2047; 63629-2291; 63629-2403; 70518-3471; 70752-167; 0603-5167; 72162-1583; 75826-143; 0904-6575; 13517-107; 13517-111; 13517-692; 13517-694; 17856-0174; 51293-625; 58118-1626; 62135-409; 63629-1035; 63629-1036; 63629-1039; 63629-2046; 63629-2049; 69367-211; 70518-2407; 70752-162; 13517-110; 13517-756; 16571-667; 16571-668; 16571-670; 0143-1495; 51293-694; 63187-895; 63629-2044; 63629-2289; 63629-2401; 63739-192; 63739-294; 69367-213; 71205-847; 71205-850; 0603-5168; 72162-1581; 75826-136; 75826-137; 51927-1015; 16571-675; 51293-628; 62135-407; 62135-411; 63629-1032; 63629-2041; 63629-2042; 63629-2048; 63629-2290; 69367-212; 70752-166; 71205-849; 71205-889; 71205-893; 72162-1582; 38779-0852; 51552-0745; 58624-0520; 59348-0011; 65319-1450; 62135-408; 63629-2404; 70166-536; 70166-537; 70518-2612; 70752-161; 75826-138; 75826-141; 13517-112; 13517-113; 13517-755; 16571-674; 17856-0678; 51293-626
UNII YQE403BP4D
Synonyms Phenobarbital | Phenylbarbital | Phenylethylbarbituric Acid | Acid, Phenylethylbarbituric | Phenemal | Phenobarbitone | Hysteps | Phenobarbital Sodium | Sodium, Phenobarbital | Phenobarbital, Monosodium Salt | Monosodium Salt Phenobarbital | Luminal | Gardenal
Chemical Information
Molecular Formula C12H12N2O3
CAS Registry Number 50-06-6
SMILES CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Ageusia17.02.07.001; 07.14.03.003--Not Available
Agitation19.06.02.001; 17.02.05.012--
Akathisia17.01.02.002; 19.06.02.006--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000488%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia megaloblastic14.12.01.003; 01.03.02.003--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blister23.03.01.001; 12.01.06.002--Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000650%Not Available
Cholestasis09.01.01.0010.000325%Not Available
Coma17.02.09.0010.000975%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.001625%Not Available
Condition aggravated08.01.03.0040.001463%Not Available
Confusional state17.02.03.005; 19.13.01.0010.000813%
Congenital anomaly03.02.01.001--Not Available
Constipation07.02.02.001--
Cough22.02.03.0010.000325%
Cycloplegia17.17.02.003; 06.05.03.002--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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