| Pharmaceutical Information |
| Drug Name |
Phenobarbital sodium |
| Drug ID |
BADD_D01753 |
| Description |
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. |
| Indications and Usage |
For the treatment of all types of seizures except absence seizures. |
| Marketing Status |
approved; investigational |
| ATC Code |
N03AA02 |
| DrugBank ID |
DB01174
|
| KEGG ID |
D00701
|
| MeSH ID |
D010634
|
| PubChem ID |
23674889
|
| TTD Drug ID |
D0Y7RW
|
| NDC Product Code |
0792-0004; 63629-2007; 75834-288; 75834-289; 66064-1017; 72162-1330; 62756-301; 63629-1998; 63629-2008; 0641-0476; 65319-1465; 72162-1329; 42494-441; 0641-0477; 54288-136; 65319-1013; 42494-442; 63629-1997; 54288-137 |
| UNII |
SW9M9BB5K3
|
| Synonyms |
Phenobarbital | Phenylbarbital | Phenylethylbarbituric Acid | Acid, Phenylethylbarbituric | Phenemal | Phenobarbitone | Hysteps | Phenobarbital Sodium | Sodium, Phenobarbital | Phenobarbital, Monosodium Salt | Monosodium Salt Phenobarbital | Luminal | Gardenal |
|
| Chemical Information |
| Molecular Formula |
C12H11N2NaO3 |
| CAS Registry Number |
57-30-7 |
| SMILES |
CCC1(C(=O)NC(=NC1=O)[O-])C2=CC=CC=C2.[Na+] |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
| Vomiting | 07.01.07.003 | - | - | | | Mental disorder | 19.07.01.002 | - | - | Not Available | | Liver injury | 12.01.17.012; 09.01.07.022 | - | - | Not Available |
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