| Pharmaceutical Information |
| Drug Name |
Phenylephrine |
| Drug ID |
BADD_D01762 |
| Description |
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.[A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.[A187376]
Phenylephrine was granted FDA approval in 1939.[L9413] |
| Indications and Usage |
Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia,[L9416, L9410] an ophthalmic formulation is indicated to dilate pupils[L9413] and induce vasoconstriction, an intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids.[A187370] Off-label uses include situations that require local blood flow restriction such as the treatment of priapism.[A187370] |
| Marketing Status |
approved |
| ATC Code |
C01CA06; R01AA04; R01AB01; R01BA03; S01FB01; S01GA05 |
| DrugBank ID |
DB00388
|
| KEGG ID |
D08365
|
| MeSH ID |
D010656
|
| PubChem ID |
6041
|
| TTD Drug ID |
D0O6IU
|
| NDC Product Code |
57218-710 |
| UNII |
1WS297W6MV
|
| Synonyms |
Phenylephrine | (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol | Metasympatol | Mezaton | Phenylephrine Hydrochloride | Phenylephrine Tannate | Tannate, Phenylephrine | Metaoxedrin | Neo-Synephrine | Neo Synephrine | Neosynephrine |
|
| Chemical Information |
| Molecular Formula |
C9H13NO2 |
| CAS Registry Number |
59-42-7 |
| SMILES |
CNCC(C1=CC(=CC=C1)O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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