| Drug Name |
Phenytoin sodium |
| Drug ID |
BADD_D01766 |
| Description |
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.[A188826,A188832]
Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects.[A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.[A189219] |
| Indications and Usage |
Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery.[L9362] Injectable phenytoin and [Fosphenytoin], which is the phosphate ester prodrug formulation of phenytoin[A188571], are indicated to treat tonic-clonic status epilepticus, and for the prevention and treatment of seizures occurring during neurosurgery.[L10740] |
| Marketing Status |
approved; vet_approved |
| ATC Code |
N03AB02 |
| DrugBank ID |
DB00252
|
| KEGG ID |
D02103
|
| MeSH ID |
D010672
|
| PubChem ID |
657302
|
| TTD Drug ID |
D0E4DW
|
| NDC Product Code |
42291-772; 63629-8529; 70518-0980; 57664-808; 62756-299; 65862-692; 0615-8020; 0641-0493; 52119-006; 66064-6001; 42192-614; 51662-1250; 63187-891; 63629-2369; 0404-9933; 71335-0232; 12711-4466; 17349-0004; 51672-4111; 53002-1501; 58118-4111; 0378-3750; 71610-479; 0009-0087; 51927-0301; 70859-008; 43063-492; 70518-1776; 51552-0532; 51662-1251; 0404-9932; 70518-2293; 0641-2555; 0904-6187; 49452-5344; 53747-082; 29300-379; 50090-3165; 50090-5700; 53002-4501; 62756-432; 65162-212; 68084-376; 70518-0107; 70518-2227; 0641-6139; 55154-7979; 0641-6138; 71335-0913; 38779-0216 |
| UNII |
4182431BJH
|
| Synonyms |
Phenytoin | Fenitoin | Diphenylhydantoin | 5,5-diphenylimidazolidine-2,4-dione | 5,5-Diphenylhydantoin | Difenin | Dihydan | Phenhydan | Epamin | Epanutin | Hydantol | Phenytoin Sodium | Sodium Diphenylhydantoinate | Diphenylhydantoinate, Sodium | Antisacer | Dilantin |
