Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pilocarpine hydrochloride
Drug ID BADD_D01771
Description A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Indications and Usage For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome. A pilocarpine ophthalmic solution is indicated for the treatment of presbyopia in adults.[L39015]
Marketing Status approved; investigational
ATC Code S01EB01; N07AX01
DrugBank ID DB01085
KEGG ID D02200
MeSH ID D010862
PubChem ID 5909
TTD Drug ID D06HLY
NDC Product Code 0228-2837; 17478-223; 63279-100; 59212-775; 61314-204; 69238-1746; 69292-265; 71335-2094; 38779-0182; 16714-121; 59651-224; 61314-206; 0527-1407; 68084-928; 69238-1747; 12538-1921; 69205-001; 59651-225; 61314-203; 0074-7098; 17478-226; 50268-652; 59212-705; 63629-2099; 0527-1313; 16714-122; 63629-8351; 69238-1745; 82133-200; 17478-224; 0228-2801; 60219-5922
UNII 0WW6D218XJ
Synonyms Pilocarpine | Isoptocarpine | Salagen | Pilocarpine Hydrochloride | Hydrochloride, Pilocarpine | Pilocarpine, Monohydrochloride, (3S-cis)-Isomer | Pilocarpine Nitrate | Nitrate, Pilocarpine | Pilocarpine Mononitrate, (3S-cis)-Isomer | Isopilocarpine | Ocusert
Chemical Information
Molecular Formula C11H17ClN2O2
CAS Registry Number 54-71-7
SMILES CCC1C(COC1=O)CC2=CN=CN2C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abnormal sensation in eye06.01.01.0010.010102%Not Available
Accommodation disorder06.02.04.0010.020947%Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.001486%
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Aphasia19.21.01.001; 17.02.03.001--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Aura17.02.07.0110.007577%Not Available
Back pain15.03.04.005--
Blepharospasm17.17.02.001; 06.05.01.001--Not Available
Blindness06.02.10.003; 17.17.01.0030.001486%Not Available
Blindness transient06.02.10.006; 17.17.01.0040.004457%Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.002--Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cataract06.06.01.001--
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