Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status approved; investigational
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 0480-3610; 60862-005; 69766-030; 76072-1006; 42385-924; 69539-120; 42385-923; 42385-925; 42571-336; 69097-940; 72205-182; 0781-8085; 0480-3611; 65372-1197; 82920-705; 16729-468; 46708-479; 69238-1640; 62332-480; 0781-2158; 62207-004; 31722-872; 50228-442; 69539-119; 57297-140; 73309-052; 46708-480; 69097-988; 69238-1641; 42571-329; 46016-5312; 31722-873; 72205-181; 76282-716; 0781-8086; 53104-7712; 69037-0013; 60219-1640; 60219-1641; 47621-311; 59285-013; 59651-199; 50228-443; 50242-121; 60219-1642; 62332-479; 46016-5310; 16729-467; 42385-926; 42571-335; 50228-441; 50242-122; 69097-987; 76282-715; 76282-717; 11014-0214; 46438-0648; 62512-0070; 50242-123
UNII D7NLD2JX7U
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dementia Alzheimer's type19.20.03.001; 17.03.06.0010.000530%Not Available
Dermatitis23.03.04.0020.001543%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.000892%Not Available
Dermatitis bullous23.03.01.0020.000362%
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.0030.000530%Not Available
Dermatitis exfoliative10.01.01.004; 23.03.07.0010.000482%
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.077277%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.000603%Not Available
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.047981%
Dry mouth07.06.01.0020.003376%
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.0010.012851%
Dyspepsia07.01.02.0010.023846%
Dysphagia07.01.06.0030.010271%
Dyspnoea02.11.05.003; 22.02.01.0040.050778%
Dyspnoea exertional02.11.05.005; 22.02.01.0050.001664%Not Available
Eating disorder19.09.01.008; 14.03.01.0080.003207%Not Available
Eczema23.03.04.0060.001591%
Embolic stroke17.08.01.032; 24.01.04.0100.000362%Not Available
Emphysema22.01.02.0020.001374%Not Available
Eructation07.01.02.0030.002411%
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.000603%
Extrasystoles02.03.02.0030.000362%Not Available
Eye disorder06.08.03.001--Not Available
Failure to thrive19.07.05.001; 14.03.02.008; 18.04.01.0030.000241%Not Available
Fasciitis15.03.03.0010.000241%Not Available
Fatigue08.01.01.0020.091020%
Feeling cold08.01.09.0080.001495%Not Available
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