Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pralatrexate
Drug ID BADD_D01814
Description Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
Indications and Usage Treatment of relapsed or refractory peripheral T-cell lymphoma.
Marketing Status approved; investigational
ATC Code L01BA05
DrugBank ID DB06813
KEGG ID D05589
MeSH ID C418863
PubChem ID 148121
TTD Drug ID D02LWU
NDC Product Code 72893-005; 47848-045; 53183-4020; 48818-001; 65219-550; 72893-003; 68554-0071; 65219-552; 65392-2510
UNII A8Q8I19Q20
Synonyms 10-propargyl-10-deazaaminopterin | pralatrexate
Chemical Information
Molecular Formula C23H23N7O5
CAS Registry Number 146464-95-1
SMILES C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.000112%
Abdominal pain07.01.05.0020.000224%
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000112%Not Available
Altered state of consciousness19.07.01.003; 17.02.04.0010.000112%Not Available
Anaemia01.03.02.0010.000448%
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.000112%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Constipation07.02.02.001--
Cough22.02.03.0010.000112%
Death08.04.01.0010.000728%
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.000112%
Diarrhoea07.02.01.001--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.0150.000112%Not Available
Dyspnoea02.11.05.003; 22.02.01.004--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema multiforme23.03.01.003; 10.01.03.0150.000112%
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.000336%
Gastrointestinal pain07.01.05.005--
Haematemesis24.07.02.011; 07.12.02.0020.000112%Not Available
Hepatic function abnormal09.01.02.0010.000112%Not Available
Hypokalaemia14.05.03.002--
Insomnia19.02.01.002; 17.15.03.0020.000112%
Interstitial lung disease10.02.01.033; 22.01.02.0030.000224%Not Available
Laryngeal pain22.12.03.010--
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