Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Procaine
Drug ID BADD_D01844
Description A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-experienced HIV patients [L1215].
Indications and Usage Used as a local anesthetic primarily in oral surgery
Marketing Status approved; investigational; vet_approved
ATC Code C05AD05; N01BA02; S01HA05
DrugBank ID DB00721
KEGG ID D08422
MeSH ID D011343
PubChem ID 4914
TTD Drug ID D0TZ1G
NDC Product Code 51927-5144
UNII 4Z8Y51M438
Synonyms Procaine | Gerokit | Novocain | Novocaine | Procain Braun | Procain curasan | Procain Rödler | Procain Jenapharm | Procain Steigerwald | procain-loges | Procaina Serra | Procaine Hydrochloride | Hydrochloride, Procaine | Pröcaine chlorhydrate Lavoisier | Röwo Procain | Anuject | Geriocaine | Hewedolor-Procain | Lophakomp-Procain N
Chemical Information
Molecular Formula C13H20N2O2
CAS Registry Number 59-46-1
SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Agitation19.06.02.001; 17.02.05.012--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009; 22.04.02.008--Not Available
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Arachnoiditis17.06.01.001; 12.02.04.002--
Atrioventricular block02.03.01.002--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Cardiac output decreased13.14.02.001--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Erythema23.03.06.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Laryngeal oedema22.04.02.001; 23.04.01.005; 10.01.05.003--
Loss of consciousness17.02.04.004--Not Available
Meningism17.02.05.007--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Paralysis17.01.04.004--Not Available
Pruritus23.03.12.001--
Respiratory arrest22.02.01.009--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
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