| Pharmaceutical Information |
| Drug Name |
Prochlorperazine |
| Drug ID |
BADD_D01848 |
| Description |
Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors.[L6637] Prochlorperazine was first developed in the 1950s [L6643] and was first approved by the FDA in 1956. Although newer antiemetic agents such as 5-HT3 antagonists are more heavily promoted, prochlorperazine is still widely used in nausea and vomiting.[L6640] |
| Indications and Usage |
Indicated for the symptomatic treatment of severe nausea and vomiting.[label]
Indicated for the management of manifestations of psychotic disorders, such as schizophrenia and generalized non-psychotic anxiety. The use of prochlorperazine for the management of generalized non-psychotic anxiety is typically not a first-line therapy and should be limited to doses of less than 20 mg per day or for shorter than 12 weeks.[label,L6634]
Off-label uses include use in emergency settings for adult and pediatric migraines. The American Headache Society recommends the use of prochlorperazine as the first-line medication in this setting. In pediatric migraines, a non-steroidal anti-inflammatory agent is often used in combination with dopamine antagonist.[L6637] |
| Marketing Status |
approved; vet_approved |
| ATC Code |
N05AB04 |
| DrugBank ID |
DB00433
|
| KEGG ID |
D00493
|
| MeSH ID |
D011346
|
| PubChem ID |
4917
|
| TTD Drug ID |
D0B2UZ
|
| NDC Product Code |
63629-8444; 54348-114; 55289-119; 69575-4017; 46204-0007; 54348-989; 0713-0135; 0574-7226 |
| UNII |
YHP6YLT61T
|
| Synonyms |
Prochlorperazine | Prochlorperazine Edisylate Salt | Edisylate Salt, Prochlorperazine | Salt, Prochlorperazine Edisylate | Prochlorperazine Edisylate | Edisylate, Prochlorperazine | Prochlorperazine Maleate | Maleate, Prochlorperazine | Compazine |
|
| Chemical Information |
| Molecular Formula |
C20H24ClN3S |
| CAS Registry Number |
58-38-8 |
| SMILES |
CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
|
|
|
