Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status approved
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-478; 24979-086; 69680-130; 69680-131; 71205-942; 12598-6285; 71205-941; 24979-087; 24979-085; 51407-477; 71205-940; 69680-132; 51407-479
UNII 68IQX3T69U
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.001045%
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agitation19.06.02.001; 17.02.05.0120.000627%
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000836%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.000627%
Angina pectoris24.04.04.002; 02.02.02.0020.000627%
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Anxiety19.06.02.0020.001045%
Apnoea22.02.01.001--
Arrhythmia02.03.02.0010.003762%Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.0010.001672%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.0020.004891%
Atrial flutter02.03.03.0030.000627%
Atrioventricular block02.03.01.0020.000418%Not Available
Atrioventricular block first degree02.03.01.0040.001463%
Atrioventricular block second degree02.03.01.0050.000920%
Bleeding time prolonged13.01.02.002--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.04.018--
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ADReCS-Target
Drug Name ADR Term Target
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