Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Propafenone hydrochloride
Drug ID BADD_D01857
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status approved
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D00640
MeSH ID D011405
PubChem ID 36708
TTD Drug ID D0J2KV
NDC Product Code 12598-6283; 12780-4900; 49884-113; 51407-016; 59651-256; 60687-674; 63629-9280; 64380-186; 68382-523; 0591-2285; 0591-2286; 0591-2287; 12598-6216; 12598-6218; 12598-6220; 49706-0201; 16571-736; 49884-211; 51407-017; 60687-685; 64380-163; 68462-409; 0591-0582; 59285-007; 62559-230; 62559-231; 64380-184; 59651-257; 59651-258; 63629-1989; 63629-2266; 68382-524; 68462-410; 16714-827; 53489-552; 63629-1988; 63629-2269; 68382-522; 0832-0741; 60687-185; 63629-2268; 64380-165; 0603-5449; 0832-0740; 12598-6278; 16714-825; 16714-826; 53489-553; 64380-164; 70771-1525; 0832-0742; 0591-0583; 0173-0823; 49884-210; 16571-737; 16571-738; 51407-015; 59651-276; 60429-437; 62559-232; 64380-185; 70771-1526; 70771-1527; 46016-0320; 65015-671; 65841-170; 0173-0826; 53489-551; 60687-709; 63629-2105; 68462-408; 0603-5450; 12598-6280; 68108-0340; 0173-0824; 59651-277; 59651-278
UNII 33XCH0HOCD
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H28ClNO3
CAS Registry Number 34183-22-7
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Eye irritation06.04.05.003--Not Available
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
Granulocytopenia01.02.03.003--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hyponatraemia14.05.04.002--
Leukopenia01.02.02.001--Not Available
Mania19.16.02.002--
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Oesophagitis07.08.05.001--
Pain08.01.08.004--
Palpitations02.11.04.012--
Paraesthesia17.02.06.005; 23.03.03.094--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.003--
Renal failure20.01.03.005--Not Available
Seizure17.12.03.001--
Sinus arrest02.03.03.007--Not Available
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