| Pharmaceutical Information |
| Drug Name |
Protriptyline |
| Drug ID |
BADD_D01872 |
| Description |
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, alpha1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. |
| Indications and Usage |
For the treatment of depression. |
| Marketing Status |
approved |
| ATC Code |
N06AA11 |
| DrugBank ID |
DB00344
|
| KEGG ID |
D08447
|
| MeSH ID |
D011530
|
| PubChem ID |
4976
|
| TTD Drug ID |
D00MYQ
|
| NDC Product Code |
Not Available |
| UNII |
4NDU154T12
|
| Synonyms |
Protriptyline | Vivactil | Protriptyline Hydrochloride | Hydrochloride, Protriptyline |
|
| Chemical Information |
| Molecular Formula |
C19H21N |
| CAS Registry Number |
438-60-8 |
| SMILES |
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13 |
| Chemical Structure |
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| ADRs Induced by Drug |
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