Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Protriptyline hydrochloride
Drug ID BADD_D01873
Description Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, alpha1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
Indications and Usage For the treatment of depression.
Marketing Status approved
ATC Code N06AA11
DrugBank ID DB00344
KEGG ID D00484
MeSH ID D011530
PubChem ID 6603149
TTD Drug ID D00MYQ
NDC Product Code 0054-0210; 46438-0056; 0054-0211; 42794-004; 42806-096; 46438-0066; 42806-097; 17337-0539; 42794-007
UNII 44665V00O8
Synonyms Protriptyline | Vivactil | Protriptyline Hydrochloride | Hydrochloride, Protriptyline
Chemical Information
Molecular Formula C19H22ClN
CAS Registry Number 1225-55-4
SMILES CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Generalised oedema14.05.06.007; 08.01.07.004--
Gynaecomastia21.05.04.003; 05.05.02.003--
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperpyrexia08.05.02.002--Not Available
Hypoaesthesia17.02.06.023; 23.03.03.081--Not Available
Hypomania19.16.02.001--Not Available
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intraocular pressure increased13.07.04.002--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Libido increased21.03.02.007; 19.08.03.002--
Malaise08.01.01.003--
Micturition disorder20.02.02.005--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Nightmare19.02.03.003--Not Available
Nocturia20.02.03.001--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Palpitations02.11.04.012--
Panic reaction19.06.04.003--Not Available
Paraesthesia17.02.06.005; 23.03.03.094--
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