Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pyrimethamine
Drug ID BADD_D01886
Description One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Indications and Usage For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Marketing Status approved; investigational; vet_approved
ATC Code P01BD01
DrugBank ID DB00205
KEGG ID D00488
MeSH ID D011739
PubChem ID 4993
TTD Drug ID D0C0SK
NDC Product Code 63804-5300; 60592-244; 43598-672; 0480-3720; 47781-925; 40074-0008; 59651-564; 68057-001; 57451-1183; 51927-3122; 66651-922; 67763-114; 71052-215; 71554-020; 59651-590; 69413-330; 64677-0006; 71554-028; 72647-330; 51927-0237
UNII Z3614QOX8W
Synonyms Pyrimethamine | Malocide | Tindurine | Chloridin | Daraprim
Chemical Information
Molecular Formula C12H13ClN4
CAS Registry Number 58-14-0
SMILES CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000723%Not Available
Abortion spontaneous18.01.04.0010.000142%Not Available
Anaemia megaloblastic14.12.01.003; 01.03.02.003--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Arrhythmia02.03.02.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000283%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000142%
Confusional state19.13.01.001; 17.02.03.0050.000482%
Constipation07.02.02.0010.000482%
Cough22.02.03.0010.000312%
Death08.04.01.0010.000425%
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.000142%
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.000312%
Drug interaction08.06.03.0010.000213%Not Available
Dyspnoea22.02.01.004; 02.11.05.0030.000553%
Erythema multiforme23.03.01.003; 10.01.03.015--
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Headache17.14.01.0010.001204%
Hypersensitivity10.01.03.0030.000793%
Irritability19.04.02.013; 08.01.03.0110.000142%
Leukoencephalopathy17.13.02.0030.000142%
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.0040.000142%Not Available
Malaise08.01.01.0030.000482%
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000354%Not Available
Nausea07.01.07.0010.003344%
Neutropenia01.02.03.0040.000354%Not Available
Pancytopenia01.03.03.003--Not Available
Phenylketonuria17.03.07.002; 14.14.04.002; 03.08.04.002; 20.02.01.018; 19.21.06.002--Not Available
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